The Effects of Iso-8 Exposure begin to make everyday villains capable of taking on Earth's mightiest heroes. As S.H.I.E.L.D. tries to uncover why seeming rivals are coordinating their efforts, you'll need to continue developing your leadership skills and combat abilities.

Mission 1 - In the Family

In the Family
Mastery and Recommended Levels
	Level 9
- 9,000 points	Level 11
- 224,000 points	Level 13
- 448,000 points	Level 15
- 896,000 points	Level 17
- 1,792,000 points	Level 19

Unlock Requirements: 1 Star Mastery in Chapter 1 - Mission 5

Location: Little Italy
Team-Up: She-Hulk

Battles

• Low: x2
• Medium: x3
• High: x2

Enemies

• Maggia Grunt
• Maggia Henchman
• Maggia Thug
• Maggia Hitman
• Maggia Bodyguard
• Maggia Gunman
• Maggia Duelist

Mini-Boss: Minimum Cleared: 4

• Maggia Gunman
• Sandman

Boss: Minimum Cleared: 5

• Maggia Hitman
• Hamerhead

Boss Drops:

• Knuckle Sting
• Batstone 2.357 Minigun

Deploy Missions

• Requirement: Thing
• Duration: 2 Battles
• Requirement: Any Hero
• Duration: 1 Battle
• Requirement: Any Hero
• Duration: 1 Battle

Mission 2 - The Sound of Feathers Ruffling

The Sound of Feathers Ruffling
Mastery and Recommended Levels
	Level 10
- 9,000 points	Level 12
- 205,000 points	Level 14
- 410,000 points	Level 16
- 820,000 points	Level 18
- 1,640,000 points	Level 20

Unlock Requirements:

Location: Bellevue Hospital

Team-Up: Spider-Man

Battles

• Low: x2
• Medium: x2
• High: x2

Mini-Boss: Minimum Cleared: 3

• Crimson Dynamo
• Phvsicist

Boss: Minimum Cleared: 5

• Wave 1: Guard, Guard, Guard
• Wave 2: Vulture, Biotechnician

Boss Drops:

• Pyro-Tonfa
• Third Law Nullifier

Deploy Missions

• Requirement: Any Hero
• Duration: 1 Battle
• Requirement: Any Tactician
• Duration: 2 Battles
• Requirement: Ms. Marvel
• Duration: 1 Battle
  

Mission 3 - Step into the Shadows

Step into the Shadows
Mastery and Recommended Levels
	Level 11
- 9,000 points	Level 13
- 328,000 points	Level 15
- 656,000 points	Level 17
- 1,312,000 points	Level 19
- 2,624,000 points	Level 21

Unlock Requirements:

• 1 Star Mastery in Mission 2
• Find X Decryption Devices. (randomly drop in Mission 2 battles)

Location: Hell's Kitchen

Team-Up: Daredevil

Battles

• Low: x2
• Medium: x3
• High: x2

Enemies

• Hand Soldier
• Hand Shinobi
• Hand Assassin
• Hand Warrior
• Hand Scorpion
• Hand Shadow
• Hand Dragon
• Mindless One

Mini-Boss: Minimum Cleared: 4

• Wave 1: Hand Ninja, Hand Ninja
• Wave 2: Hand Ninja, Hand Ninja, Hand Ninja

Boss: Minimum Cleared: 5

• Wave 1: Hand Shinobi, Hand Assassin
• Wave 2: Hand Scorpion, Bullseye

Boss Drops:

• Chain Blade
• Assault Shotgun

Deploy Missions

• Requirement: Black Cat
• Duration: 2 Battles
• Unique Drop: Nano-nurse
• Requirement: Any Scrapper
• Duration: 2 Battles
• Requirement: Any Hero
• Duration: 1 Battle

Epic Boss

Must finish ALL battles and deploys before the Epic Boss will appear

• Hand Shadow
• Elektra
• Hand Shadow

Boss Drops:

• Grecian Sai
• Retractable Baton

Mission 4 - Mean People

Mean People
Mastery and Recommended Levels
	Level 12
- 8,500 points	Level 14
- 191,000 points	Level 16
- 382,000 points	Level 18
- 764,000 points	Level 20
- 1,528,000 points	Level 22

Unlock Requirements:

Location: Pier 94

Team-Up: Iron Fist

Battles

• Low: x1
• Medium: x2
• High: x2

Enemies

• Lead Foot
• Slicer
• Bullets
• Framer
• Muscle
• Knuckles
• Angler

Mini-Boss: Minimum Cleared: None

• Jack O'Lantern
• Knuckles

Boss: Minimum Cleared: 5

• Wave 1: Mad Dog, Enforcer
• Wave 2: Lead Foot, The Hood

Team-Up: Iron Fist

Boss Drops:

• Tidal Fist
• S.A. "Ambush"

Deploy Missions

• Requirement: Any Hero
• Duration: 1 Battle
• Requirement: Any Bruiser
• Duration: 2 Battles
• Requirement: Luke Cage
• Duration: 1 Battle
  

Mission 5 - Mutate or Die

Mutate or Die
Mastery and Recommended Levels
	Level 13
- 11,500 points	Level 15
- 288,000 points	Level 17
- 576,000 points	Level 19
- 1,152,000 points	Level 21
- 2,304,000 points	Level 23

Unlock Requirements:

• 1 Star Mastery in Mission 4
• Find 5 Sledgehammers (randomly drop in Mission 4 battles)
• Own and Staff 3 Jets on Flight Deck

Location: Yorkville

Team-Up: Phoenix

Battles

• Low: x3
• Medium: x3
• High: x3

Enemies

• BL-Alpha
• BL-Beta
• BR-Alpha
• BR-Beta
• IN-Alpha
• IN-Beta
• SC-Alpha
• SC-Beta
• TA-Beta

Mini-Boss

• Juggernaut
• SC-Alpha
• Mystique
• SC-Alpha

Boss: Minimum Cleared: 8

• Magneto

Team-Up: Phoenix

Boss Drops:

• Batstone 2.357 Minigun
• Offensive Accelerator

Deploy Missions

• Requirement: Cyclops
• Duration: 2 Battle
• Requirement: Any Infiltrator
• Duration: 3 Battle
• Requirement: Any Hero
• Duration: 1 Battle
  

Premium Mission: Ulterior Motive

Ulterior Motive
Mastery and Recommended Levels
	Level 14
- 11,500 points	Level 16
- 241,000 points	Level 18
- 482,000 points	Level 20
- 964,000 points	Level 22
- 1,928,000 points	Level 24

Location: Avengers Mansion

Team-Up: Iron Man

Battles

• Medium: x3
• High: x2

Enemies

• Hacked Servoguard
• Hacked Servoguard
• Hacked Servoguard

Mini-Boss: Minimum Cleared: 1

• Sentinel Alpha MK IV
• Sentinel Alpha MK IV

Minimum Cleared: 2

• Nimrod Series MK IV
• Nimrod Series MK IV

Boss: Minimum Cleared: 7

• Crimson Dynamo

Boss Drops:

• EMP Blaster
• Uni-Pulse

Deploy Missions

• Requirement: Any Blaster
• Duration: 1 Battle
• Requirement: Any Hero
• Duration: 2 Battle
• Requirement: War Machine
• Duration: 1 Battle